361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study utilizes patient-derived human cardiac organoids to demonstrate that LMNA haploinsufficiency triggers early, reversible multicellular remodeling and profibrotic signaling prior to the onset of overt dilated cardiomyopathy, highlighting a potential window for therapeutic intervention.
This study reveals that the yeast transcription factor Cbf1 stabilizes the budding yeast kinetochore by forming an interdependent, mutually reinforcing interaction with the inner kinetochore protein Okp1, which is essential for both CCAN assembly and the protein's own stable centromeric association.
This study identifies the GPI-anchored protease MT4-MMP as a critical regulator of embryonic brain angiogenesis that maintains vascular balance by cleaving the co-receptor NRP1 to modulate VEGFA-induced ERK signaling, thereby preventing excessive vessel formation.
This study demonstrates that SUMO protein abundance positively correlates with and functionally regulates meiotic crossover rates across diverse vertebrate species and within goat breeds, establishing SUMO as a central mediator of genetic diversity and chromosome segregation.
This study demonstrates that the newly synthesized organotin(IV) dithiocarbamate DioSn-2 exhibits potent and selective cytotoxicity against A549 lung cancer cells by inducing mitochondria-mediated apoptosis through oxidative stress and caspase-9 activation, positioning it as a promising alternative to cisplatin.
This study identifies the sodium-bicarbonate cotransporter NBCn1 as a critical ciliary membrane component that interacts with DYNLL1 to regulate ciliary length and SUFU localization, thereby controlling Sonic hedgehog signaling.
This study reveals that the ribosomal protein paralog Rpl12b specifically regulates TORC1 signaling and Stm1 expression to control ribosome stability, stress adaptation, and cellular longevity in *Saccharomyces cerevisiae*.
By combining CRISPR-Cas9 gene editing with live-cell imaging and proximity labeling, this study reveals that GGAs localize to distinct Golgi and peripheral compartments where they independently recruit clathrin and regulate AP-1-dependent trafficking by preventing premature AP-1 binding to its cargo, thereby modulating bi-directional transport between the Golgi and endosomes.
This study demonstrates that the interplay between the severing enzyme katanin, minus-end stabilizers CAMSAPs and WDR47, and the depolymerase kinesin-13 fine-tunes microtubule minus-end stability and abundance through a concentration-dependent balance of amplification and disassembly.
The paper introduces Brieflow, an integrated computational pipeline for high-throughput analysis of optical pooled screening data, coupled with the MozzareLLM framework for LLM-driven biological interpretation, to overcome existing analytical challenges and uncover novel biological modules such as core mitochondrial sub-programs.