599 papers
This study reveals that c-MYC is an aggregation-prone, amyloidogenic protein whose spontaneous formation of amyloid oligomers induces transcription-independent apoptosis, suggesting a built-in failsafe mechanism that contributes to its paradoxical tumor-suppressing activity.
Using live-imaging of over 150 HCT116 cell lineages, this study reveals that multipolar chromosome segregation in early mitosis is the primary factor limiting post-whole-genome duplication proliferation, with successful lineages either mitigating this risk in one sub-lineage or surviving despite early multipolar events.
This study demonstrates that oxygen levels and environmental mechanics are reciprocally coupled regulators that jointly determine distinct cellular states by differentially altering global chromatin accessibility in 3D ECM-like contexts.
This study demonstrates that distinct regions of the Nanog mRNA, specifically the coding sequence and 3' UTR, function independently and asymmetrically to coordinate separate aspects of pluripotent cell behavior, with the 3' UTR regulating morphogenesis and cytoskeletal organization while the coding sequence controls transcriptional and epigenetic programs.
This study reveals that gut tumors in *Drosophila* secrete Pvf1 to activate the TORC1-Hnf4 signaling pathway in distal hepatocyte-like oenocytes, reprogramming their lipid metabolism to produce specific fatty acids that fuel tracheal growth and tumor progression, a mechanism conserved in mammals that offers potential therapeutic targets for cancer-associated metabolic disorders.
This paper introduces DL-TCP-FRET, a novel dual-logistic analysis method that integrates time- and concentration-dependent phenotypic characteristics with target-specific FRET efficiency to generate a unified efficacy score, thereby enhancing the accuracy and efficiency of identifying targeted anticancer drugs for precision medicine.
This study identifies the nuclear-cytoskeletal interface as a critical vulnerability in aging endothelial cells, demonstrating that Progerin-induced disruption of LINC complex-mediated connections impairs nuclear positioning and flattening, thereby blocking angiogenic sprouting and lumen formation to drive microvascular dropout.
This study demonstrates that while intrinsic internalization of positively charged protein cargos is charge-dependent and limited by surface saturation, the efficacy of calcium-dependent cell-penetrating peptide adaptors varies significantly based on cargo charge, with specific adaptor designs capable of overcoming these limits or inhibiting uptake depending on their own electrostatic properties.
This study demonstrates that synergistically inhibiting Notch signaling via Rbpj deletion and forcing Müller glia cell cycle re-entry through cyclin D1 overexpression and p27Kip1 suppression effectively drives the reprogramming of uninjured mouse Müller glia into long-surviving, subtype-specific retinal neurons.
This study reveals that obesity drives sex-specific remodeling of human subcutaneous adipose tissue vasculature, characterized by inflammatory mural cell loss and endothelial activation in males versus preserved structural integrity and adaptive metabolic pathways in females, thereby establishing the adipose endothelium as a key sex-divergent regulator of cardiometabolic risk.
This study demonstrates that NBR1, like its partner p62, shuttles between the cytoplasm and nucleus via specific signal motifs and is essential for the formation of nuclear p62 bodies.
This study identifies deep invaginations of the nuclear envelope (DINEs) as intrinsic, mechanosensitive structures in epithelial cells that coordinate nuclear shape, chromatin organization, and gene activity in response to mechanical forces and tissue maturation.
This study demonstrates that inhibiting acid sphingomyelinase (ASMase) prevents necroptotic cell death by reducing ceramide accumulation, which impairs the ability of activated MLKL to form membrane pores and cause permeabilization without affecting upstream signaling.
By employing a biomimetic system with fluid supported lipid bilayers to control E-cadherin mobility, this study reveals that the dynamic movement of cadherins dictates local shifts between formin-based linear and Arp2/3-based branched actin architectures during adherens junction formation and maturation.
This study reveals that HIV-1 infection depletes the sodium/hydrogen exchanger NHE6 to drive endosomal acidification, a process essential for the viral protein Nef to downmodulate MHC-I and evade immune detection, whereas restoring NHE6 levels neutralizes endosomal pH and disrupts this immune evasion mechanism.
This paper introduces TOPAZ, a novel computational pipeline that integrates topological data analysis with Bayesian inference methods to effectively infer parameters and select the most biologically plausible agent-based models from spatiotemporal single-cell imaging data.
The study reveals that larger cells exhibit increased resistance to ferroptosis due to a size-dependent proteomic reprogramming that enhances glutathione production and lipid peroxide detoxification while reducing the expression of pro-ferroptotic factors like ACSL4.
This study reveals that clonal hematopoiesis driven by *TP53* mutations promotes tissue repair in acute cardiovascular diseases by enhancing the pro-angiogenic and phagocytic capabilities of mutant macrophages through suppressed E2F signaling and increased VEGF expression.
This study demonstrates that while cell line identity is the primary determinant of transcriptomic profiles in HepaRG and HuH7 cells, switching from serum-based to chemically defined media differentially enhances xenobiotic metabolism in HepaRG cells to better resemble primary human hepatocytes, whereas HuH7 cells primarily exhibit stress and lipid homeostasis responses.
This study demonstrates that while lipoxin treatment does not fully reverse cardiac dysfunction or fibrosis in MLPko mice, it provides sex-specific protective effects by modulating immune cell populations, intercalated disk-associated signaling, and pro-fibrotic gene expression.